WIRED – The “super flu” behind outbreaks in the US and UK is a new variant of influenza A H3N2, subclade K. Here’s what you need to know.
The spread of influenza became more severe this fall, particularly in the United States and the United Kingdom.
The US Centers for Disease Control and Prevention has designated the 2024-25 flu season as the most severe season since 2017-18. In the UK, the spread has begun earlier than at any time since 2003-04.
Against this backdrop, some media outlets have begun using the term “super flu.” However, this term is not an official medical term. The actual name is “subclade K,” a new variant of influenza A H3N2.
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This variant has multiple mutations in a protein on the surface of the virus called hemagglutinin, making it antigenically different from the variants used in existing vaccines.
This allows it to partially evade immunity acquired through previous infection or vaccines, making people more susceptible to infection. Genetic analysis by the UK Health Security Agency has revealed that 87 percent of H3N2 viruses detected since late August 2025 are subclade K.
The Outbreak Began Earlier Than Usual
The term “super flu” is not necessarily scientifically accurate. The H3N2 strain already caused severe illness in the elderly and children, and the new mutant strain has not made it more deadly.
Contrary to the name, the virus’s inherent danger is said to be no different from the conventional H3N2 strain.
In 2025, the US influenza pandemic peaked in early February, with active epidemics occurring in 87.3 percent of the country. For 11 consecutive weeks, more than 50 percent of the country recorded high epidemic levels, an anomaly that led to 287 child deaths.
However, these figures reflect the scale of the epidemic and do not imply an increase in the lethality of the virus itself …
